In a large skillet over medium heat, melt the butter.
Add the onions and cook for 3-5 minutes or until they start to become translucent and soft.
Add the sweet bell peppers and jalapeno. Cook for 2-3 minutes.
Add garlic and continue to cook for another 2 minutes.
Remove from heat and allow to cool slightly.
Meanwhile in a large bowl, combine saltine crumbs, egg, milk, ketchup, mustard, Worcestershire sauce, salt and pepper.
Add vegetables to the mixture, stirring to combine.
Mix in the meat, using your hands to fully combine all the ingredients together but don't overwork the mixture.
Place the meat mixture into a 9 inch bread pan and pressing the meat together to form a loaf.
In a small bowl, whisk together all the glaze ingredients and pour half over the meatloaf evenly.
Place the meatloaf in the fridge to set, about 10 minutes.
Preheat smoker to 300℉.
Place meatloaf in the preheated smoker.
Cook for 1.5 hours, turning halfway through cooking.
Baste meatloaf with half the remaining glaze after 1 hour of cooking.
Meatloaf is ready when the internal temperature reaches 150℉. Meatloaf will continue to cook as it rests.
Remove from smoker and allow to rest for 10-15 before slicing.